5.05017

UBP310

• 別名: UBP310, GluK1/GluK3 antagonist, UBP310, (S)-1-(2-Amino-2-carboxyethyl)-3-(2­-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine­-2,4-dione, UBP-310, UBP 310
• 実験式（ヒル表記法）: C₁₄H₁₅N₃O₆S
• CAS番号: 902464-46-4
• 分子量: 353.35
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: solid
• 有効性: 10 nM K_i
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 100 mM
• 保管温度: 2-8°C
• InChI: 1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
• InChI Key: ZTAZUCRXCRXNSU-VIFPVBQESA-N

詳細

詳細

A potent antagonist highly selective for GluK1 (K_b = 10 nM), GluK3 (IC₅₀ = 23 nM), and GluK1/K5 (K_b = 8 nM) subtype kainate receptors. Does not interact with GluK2 and GluK2/K5 receptors. Low affinity to AMPA receptors (K_d = 83 µM). Does not interact with mGluR1 or NMDA receptors at concentration less than 10 µM. Often used in studying neuronal excitability and synaptic plasticity.

生物化学的／生理学的作用

Primary Target
GluK1

Secondary Target
Gluk3

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Pinheiro, S., et al. 2013. Cereb. Cort.23, 323.
Atlason, T., et al. 2010. Mol. Pharmacol.78, 1036.
Perrais, D., et al. 2009. Neuropharmacol.56, 131.
Dolman, P., et al. 2007. J. Med. Chem.50, 1558.
Mayer, L., et al. 2006. J. Neurosci.26, 2852.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable