481408-M

NF-κB Activation Inhibitor II, JSH-23

The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 別名: NF-κB Activation Inhibitor II, JSH-23, 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
• 実験式（ヒル表記法）: C₁₆H₂₀N₂
• CAS番号: 749886-87-1
• 分子量: 240.34
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 10 mg/mL
• 保管温度: −20°C
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• InChI Key: YMFNPBSZFWXMAD-UHFFFAOYSA-N

詳細

詳細

A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC₅₀ = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.

A cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC₅₀ = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.

生物化学的／生理学的作用

Primary Target
Blocks nuclear translocation of NF-κB p65 and its transcription activity

Target IC₅₀: 7.1 µM in a NF-κB reporter assay using RAW 264.7

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Shin, H.M., et al. 2004. FEBS Lett.571, 50.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3