208724

Calpain Inhibitor IV

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: Calpain Inhibitor IV, Z-LLY-FMK
• 実験式（ヒル表記法）: C₃₀H₄₀FN₃O₆
• 分子量: 557.65
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated
• 色: white to pale yellow
• 溶解性: DMSO: 25 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
calpain 2

Product does not compete with ATP.

Reversible: no

k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

警告

Toxicity: Standard Handling (A)

シーケンス

Z-Leu-Leu-Tyr-CH₂F

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

アナリシスノート

single spot by TLC

その他情報

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable