204882

Complement C2, Human

Complement C2, Human, is a native, single chain glycoprotein present. C2 is cleaved by the activated C1s into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment.

• 別名: C2 Protein
• UNSPSCコード: 12352202
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥90% (SDS-PAGE)
• 形状: liquid
• 比活性: ≥4×10⁵ C2H50 units/mg (>=70% of the C2 activity in normal human serum on a mg/mg basis)
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles
• 不純物: C1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin, trace
• 輸送温度: wet ice
• 保管温度: −70°C

詳細

詳細

Native, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.

包装

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

物理的形状

In PBS, pH 6.0.

調製ノート

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

再構成

Following initial thaw, aliquot and freeze (-70°C).

その他情報

Attwood, J.T., et al. 2001. Acta Paediatr.90, 99.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable