203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

• 別名: Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
• 実験式（ヒル表記法）: C₂₀H₁₃N₃O₂
• CAS番号: 119139-23-0
• 分子量: 327.34
• MDL番号: MFCD00236432
• UNSPSCコード: 12352111

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• 形状: powder; solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: dark orange
• 溶解性: methanol: 10 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• InChI Key: DQYBRTASHMYDJG-UHFFFAOYSA-N

詳細

詳細

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

生物化学的／生理学的作用

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable