主要文書

すべての文書を表示

スキップする

200499

Bexarotene

Name: Bexarotene
Brand: MM

≥96% (HPLC), retinoid X receptor agonist, powder

別名:

Bexarotene, 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

ログインで組織・契約価格をご覧ください。

サイズを選択してください

表示を変更する

あなたへ/カタログ番号	在庫状況	単価

この商品について

実験式（ヒル表記法）:

C₂₄H₂₈O₂

CAS番号:

153559-49-0

分子量:

348.48

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00932428

Assay:

≥96% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

この製品は、Merck Milliporeウェブサイトでのみ注文できます。

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

特性

製品名

Bexarotene, A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.

Quality Segment

100

assay

≥96% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to orange

solubility

DMSO: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

OC(=O)c1ccc(cc1)C(=C)c2cc3c(cc2C)C(CCC3(C)C)(C)C

InChI

1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)

InChI key

NAVMQTYZDKMPEU-UHFFFAOYSA-N

詳細

General description

A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cramer, P.E., et al. 2012. Science Exp.335, 1503.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

類似品目との比較

比較内容をすべて表示

相違点を表示

1 of 1

当該品目	616463	SML0282	654085
Sigma-Aldrich 200499 Bexarotene	Sigma-Aldrich 616463 TGF-β RI Kinase Inhibitor IX	Sigma-Aldrich SML0282 ベキサロテン	Sigma-Aldrich 654085 TTNPB
assay ≥96% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
storage condition OK to freeze, protect from light	storage condition OK to freeze, protect from light	storage condition -	storage condition OK to freeze, protect from light

Still not finding the right product?

Explore all of our products under Bexarotene

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c