おすすめの製品
由来生物
human
品質水準
リコンビナント
expressed in baculovirus infected Sf21 cells
分子量
Mw 77 kDa
メーカー/製品名
Upstate®
テクニック
activity assay: suitable (kinase)
NCBIアクセッション番号
UniProtアクセッション番号
遺伝子情報
human ... PIP5K1C(23396)
詳細
N-terminal 6His-tagged, recombinant human PIP5K1γ, full length.
Product Source: Expressed by baculovirus in Sf21 insect cells
アプリケーション
Research Category
細胞シグナル伝達
細胞シグナル伝達
Research Sub Category
腫瘍学
炎症及び自己免疫疾患
糖尿病
アルツハイマー病
神経変性疾患
腫瘍学
炎症及び自己免疫疾患
糖尿病
アルツハイマー病
神経変性疾患
Active, N-terminal 6His-tagged, recombinant human PIP5K1γ, full length. For use in Kinase Assays.
生物化学的/生理学的作用
Protein Target: PIP5K1γ
Target Sub-Family: PIPK
包装
Also available in 250μg size as catalog # 14-845M - Call for pricing and availability.
品質
Routinely evaluated in the PIProfiler.
物理的形状
Immobilized metal affinity chromatography (IMAC)
10µg of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
保管および安定性
6 months at -70°C
その他情報
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C.
Journal of biomolecular screening, 20(5), 655-662 (2014-12-24)
Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) regulate a variety of cellular processes, including signaling through G protein-coupled receptors (GPCRs), endocytosis, exocytosis, and cell migration. These lipid kinases synthesize phosphatidylinositol 4,5-bisphosphate (PIP2) from phosphatidylinositol 4-phosphate [PI(4)P]. Because small-molecule inhibitors of these lipid kinases
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