06-680-AF488

Anti-Androgen Receptor Antibody, Alexa Fluor^™ 488 Conjugate

from rabbit, ALEXA FLUOR^™ 488

• 別名: Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4
• UNSPSCコード: 12352203
• eCl@ss: 32160702

特性

• 由来生物: rabbit
• 結合体: ALEXA FLUOR^™ 488
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 交差性: human, rat
• 交差性（ホモロジーによる予測）: horse (based on 100% sequence homology), mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), canine (based on 100% sequence homology)
• テクニック: immunocytochemistry: suitable
• NCBIアクセッション番号: NP_036634
• UniProtアクセッション番号: P15207
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... AR(367)

詳細

詳細

Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.

免疫原

Epitope: This antibody recognizes the Modulating Region within the N-terminal of androgen receptor.

KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
ホルモン及び受容体

Detect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor^™ 488 Conjugate validated for use in Immunocytochemistry.

The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.

品質

Evaluated by Immunocytochemistry in MCF-7 cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Androgen Receptor in MCF-7 cells.

ターゲットの説明

~110 kDa observed.

物理的形状

Affinity purified

Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

法的情報

ALEXA FLUOR is a trademark of Life Technologies

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable