おすすめの製品
アッセイ
97%
形状
solid
mp
169-171 °C (lit.)
官能基
carboxylic acid
fluoro
SMILES記法
OC(=O)c1ccccc1-c2ccc(cc2)C(F)(F)F
InChI
1S/C14H9F3O2/c15-14(16,17)10-7-5-9(6-8-10)11-3-1-2-4-12(11)13(18)19/h1-8H,(H,18,19)
InChI Key
IQOMYCGTGFGDFN-UHFFFAOYSA-N
詳細
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been tested as an effective hypolipidemic agent in animal species. It has been shown to cause significant reduction in serum cholesterol and triglyceride levels in animal models and would be beneficial in therapy for hyperlipidemia. Synthesis of 4′-(trifluoromethyl)-2-biphenylcarboxylic acid (xenalipin) has been reported. Xenalipin has been synthesized in the [14C]-labelled form, with specific activity 21.0mCi/mmol, which is suitable for the metabolism and distribution studies in animals.
アプリケーション
4′-(Trifluoromethyl)-2-biphenylcarboxylic acid may be used in chemical synthesis.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
346357-25G:
346357-BULK:
346357-1G:
346357-100G:
346357-5G:
346357-VAR:
Atherosclerosis, 64(1), 27-35 (1987-03-01)
Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in serum cholesterol and triglycerides were observed in cholesterol-cholic acid-fed rats following oral doses of 10-30
Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent.
Journal of Labelled Compounds & Radiopharmaceuticals, 31(12), 1011-1017 (1992)
The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin.
Organic preparations and procedures international, 27(3), 367-372 (1995)
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