SHC1
SHC (Src homology 2 domain containing) transforming protein 1
別名:
SHC, SHCA
Species:
Human SHC1 (6464), Mouse Shc1 (20416), Rat Shc1 (85385), Zebrafish shc1 (323818), naked mole-rat Shc1 (101717434), domestic guinea pig Shc1 (100734561), cow SHC1 (507196), sheep SHC1 (101113548), Horse SHC1 (100063053), domestic cat SHC1 (101092911) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(6464) Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Mouse(20416) src homology 2 domain-containing transforming protein C1
- Rat(85385) SHC (Src homology 2 domain containing) transforming protein 1
- Zebrafish(323818) SHC (Src homology 2 domain containing) transforming protein 1
- naked mole-rat(101717434) SHC (Src homology 2 domain containing) transforming protein 1
- domestic guinea pig(100734561) SHC (Src homology 2 domain containing) transforming protein 1
- cow(507196) SHC (Src homology 2 domain containing) transforming protein 1
- sheep(101113548) SHC (Src homology 2 domain containing) transforming protein 1
- Horse(100063053) SHC (Src homology 2 domain containing) transforming protein 1
- domestic cat(101092911) SHC (Src homology 2 domain containing) transforming protein 1
- dog(490439) SHC (Src homology 2 domain containing) transforming protein 1
- chicken(395934) SHC (Src homology 2 domain containing) transforming protein 1
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Antibodies
製品番号
詳細
交差性
アプリケーション
Anti-Pan Shc Antibody, clone 3A12.1, clone 3A12.1, from mouse,
交差性
human
アプリケーション
immunohistochemistry
western blot
western blot
Anti-SHC1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Anti-phospho-SHC1 (pTyr349) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse
アプリケーション
immunofluorescence
western blot
western blot
Anti-Phospho-SHC1-Y427 antibody produced in rabbit, ,
交差性
human, mouse
アプリケーション
western blot
Anti-phospho-SHC Antibody (Tyr239, Tyr240), from rabbit, purified by affinity chromatography,
交差性
bovine, chicken, human, mouse, rat, rhesus macaque
アプリケーション
western blot