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Merck

PRKCA

protein kinase C, alpha

別名:
AAG6, PKC-alpha, PKCA, PRKACA
Species:
UniProtKB ID:
遺伝子ID:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

Custom & Knockdown Gene Products

Small Molecule - Activator

製品番号
詳細
Species
PKC Lipid Activator, ,
Species
human

Small Molecule - Agonist

製品番号
詳細
Species
オレイン酸, ≥99% (GC),
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
交差性
human, mouse, rat
アプリケーション
ELISA
immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-phospho-PKCα (Ser657/Tyr658) Antibody, Upstate®, from rabbit,
交差性
human, rabbit, rat
アプリケーション
ELISA
immunoprecipitation (IP)

western blot
Anti-Phospho-PKCalpha-S226 antibody produced in rabbit, ,
交差性
human, mouse, rat
アプリケーション
western blot
Anti-Phospho-PKC (pan) (βII Ser660) antibody produced in rabbit, ,
交差性
human, mouse, rat
アプリケーション
western blot
Anti-PKC α antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
D-スフィンゴシン, synthetic,
Species
rat
1-オレオイル-2-アセチル-sn-グリセリン, ≥97% (TLC), oil,
Species
human
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
Species
rat, human
(S)-(+)-カンプトテシン, ≥90% (HPLC), powder,
Species
rat, mouse, human
Bisindolylmaleimide IV, ≥98% (TLC), solid,
Species
human, rat

Proteins

製品番号
詳細
Species
プロテインキナーゼ Cαアイソザイム ヒト, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Species
human
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Species
human
PKC-α, active, GST tagged from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting mouse Prkca,
Species
mouse
MISSION® esiRNA, targeting human PRKCA,
Species
human

Small Molecule - Substrate

製品番号
詳細
Species
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
Species
human
PKC Substrate Cocktail, ,
Species
human
PKC Substrate Peptide 2, ,
Species
human