DIO3
deiodinase, iodothyronine, type III
別名:
5DIII, D3, DIOIII, TXDI3
Species:
Human DIO3 (1735), Mouse Dio3 (107585), Rat Dio3 (29475), naked mole-rat Dio3 (101697914), Domestic Rabbit DIO3 (100357267), Horse DIO3 (100146344), sheep DIO3 (100142657), dog DIO3 (612596), domestic cat DIO3 (101094186), chicken DIO3 (395939)
UniProtKB ID:
遺伝子ID:
- Human(1735) Summary: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
- Mouse(107585) deiodinase, iodothyronine type III
- Rat(29475) deiodinase, iodothyronine, type III
- naked mole-rat(101697914) deiodinase, iodothyronine, type III
- Domestic Rabbit(100357267) deiodinase, iodothyronine, type III
- Horse(100146344) deiodinase, iodothyronine, type III
- sheep(100142657) deiodinase, iodothyronine, type III
- dog(612596) deiodinase, iodothyronine, type III
- domestic cat(101094186) deiodinase, iodothyronine, type III
- chicken(395939) deiodinase, iodothyronine, type III
- cow(494549) deiodinase, iodothyronine, type III
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Antibodies
製品番号
詳細
交差性
アプリケーション
Anti-DIO3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
ANTI-DIO3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
交差性
human
アプリケーション
immunohistochemistry
western blot
western blot