U2508

Ubiquitin Carrier Protein H2 human

• MDL number: MFCD04041190
• UNSPSC Code: 12352202
• NACRES: NA.56

Properties

• biological source: human
• Quality Level: 200
• recombinant: expressed in E. coli (GST-tagged)
• Assay: >95% (SDS-PAGE)
• form: solution
• mol wt: ~14 kDa
• UniProt accession no.: P61088; P62256
• application(s): cell analysis
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... UBE2H(7328) , UBE2N(7334)

Description

Biochem/physiol Actions

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event.

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. TNF-α was shown to stimulate expression of UbcH2 in skeletal muscle cells by increasing binding of NFκ-B to the promoter region of UbcH2, inducing transcription.

Physical form

Solution in 50 mM HEPES, 50 mM NaCl, 10% glycerol, 1mM DTT, pH 7.8

Other Notes

manufactured for Sigma by Boston Biochem. Inc.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable