Skip to Content
Merck
All Photos(2)

Documents

Safety Information

T3439

Sigma-Aldrich

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

MDL number:
MFCD02689207
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

Assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.4-1 ng/mL ED50

mol wt

48 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P20333

storage temp.

−20°C

Gene Information

human ... TNFRSF1B(7133)

Application

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human may be used to study signaling of apoptosis and NF-κB activation.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 0.25 ng/ml recombinant human TNF-α.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

T3439-50UG:
T3439-VAR:
T3439-50UG-PW:
T3439-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

S Sweitzer et al.
Neuroscience, 103(2), 529-539 (2001-03-14)
The expression of interleukin-1beta and tumor necrosis factor has previously been shown to be up-regulated in the spinal cord of several rat mononeuropathy models. This present study was undertaken to determine whether blocking the action of central interleukin-1beta and tumor

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service