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T1147

Sigma-Aldrich

apo-Transferrin human

powder, BioReagent, suitable for cell culture, ≥98% (agarose gel electrophoresis)

Synonym(s):

Human transferrin, Siderophilin

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About This Item

CAS Number:
11096-37-0
EC Number:
234-318-8
MDL number:
MFCD00130536
UNSPSC Code:
12352202
NACRES:
NA.75

biological source

human plasma

product line

BioReagent

Assay

≥98% (agarose gel electrophoresis)

form

powder

mol wt

76-81 kDa

concentration

~25 mM

technique(s)

cell culture | mammalian: suitable

impurities

HIV and HBsAg, source material tested negative
≤0.005% iron

solubility

H2O: 50 mg/mL

UniProt accession no.

P02787

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TF(7018)

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Application

Apo-Transferrin human can be supplemented with iron or used to bind free iron present in media. It is also used to transport iron into mammalian cells.

Biochem/physiol Actions

Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human apo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Apo-transferrin can be loaded with iron prior to use or added directly to an iron containing medium.

Other Notes

Non-heme iron-transport protein.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

T1147-10G:
T1147-500MG:
T1147-BULK:
T1147-5X100MG:
T1147-5G:
T1147-VAR:
T1147-100MG:
T1147-1G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PloS one, 9(5), e96858-e96858 (2014-05-08)
H1 linker histone proteins are essential for the structural and functional integrity of chromatin and for the fidelity of additional epigenetic modifications. Deletion of H1c, H1d and H1e in mice leads to embryonic lethality by mid-gestation with a broad spectrum
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ASN neuro, 6(1), e00135-e00135 (2014-01-31)
The molecular requirements for human myelination are incompletely defined, and further study is needed to fully understand the cellular mechanisms involved during development and in demyelinating diseases. We have established a human co-culture model to study myelination. Our earlier observations
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Analytica chimica acta, 995, 43-51 (2017-11-12)
The Multicommutated Flow Analysis (MCFA) system for the estimation of clinical iron parameters: Serum Iron (SI), Unsaturated Iron Binding Capacity (UIBC) and Total Iron Binding Capacity (TIBC) has been proposed. The developed MCFA system based on simple photometric detection of
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