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Key Documents

Safety Information

SRP0526

Sigma-Aldrich

B7-1 (CD80), FC Fusion, Biotin Labeled

recombinant, expressed in HEK 293 cells

Synonym(s):

CTLA-4 Counter-Receptor B7.1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

recombinant

expressed in HEK 293 cells

form

frozen liquid

mol wt

52.5 kDa

UniProt accession no.

P33681

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CD8O(941)

General description

CD80 or B7-1 is expressed in the antigen-presenting cells (APC). The CD80 gene is mapped to human chromosome 3q13.33.
Human secreted B7-1-Fc fusion protein, also known as CD80, with C-terminal Avitag™ . GenBank Accession No. NM_005191, a.a 35-242 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avitag™ technology. MW = 52.5 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

Biochem/physiol Actions

CD80 is an efficient costimulatory molecule essential for immune surveillance during carcinogenesis. It inhibits cancer progression. It regulates the T cell activation to control immune response. Cell stress increases the CD80 expression. Reduced expression of CD80 is observed in colon carcinoma. High levels of CD80 stimulate anti-tumor immune responses. Therefore, enhancing CD80 expression in tumors might serve as a potent approach for cancer immunotherapy. Urinary CD80 is recognized as an important biomarker for idiopathic nephrotic syndrome (INS). CD80 might be involved in proteinuria, actin reorganization, and podocyte migration. Its expression in podocytes is associated with minimal change disease (MCD).

Physical form

Aqueous solution

Legal Information

AviTag is a trademark of Avidity, LLC

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP0526-50UG:

Certificates of Analysis (COA)

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Frank A Schildberg et al.
Immunity, 44(5), 955-972 (2016-05-19)
Immune responses need to be controlled for optimal protective immunity and tolerance. Coinhibitory pathways in the B7-CD28 family provide critical inhibitory signals that regulate immune homeostasis and defense and protect tissue integrity. These coinhibitory signals limit the strength and duration
Gabriel Cara-Fuentes et al.
Pediatric nephrology (Berlin, Germany), 35(10), 1887-1896 (2020-05-14)
Urinary CD80 has emerged as potential biomarker in idiopathic nephrotic syndrome (INS). However, its cellular source remains controversial. The aim of the study was to assess whether CD80 is truly expressed by glomerular cells in INS patients during relapse and
Melania Scarpa et al.
Oncoimmunology, 10(1), 1907912-1907912 (2021-04-20)
CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit cancer progression; however, the current understanding of the regulation of its expression on human tumor cells is limited. The TP53 tumor suppressor plays a

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