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Safety Information

SRP0159

Sigma-Aldrich

Histone H3 peptide (1-21) human

≥90% (HPLC)

Synonym(s):

HIST1H3E, Histone H3.1

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160 NMOL
¥47,800

¥47,800

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160 NMOL
¥47,800

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

¥47,800

Check Cart for Availability
Request a Bulk Order

biological source

human

Assay

≥90% (HPLC)

form

aqueous solution

mol wt

~2 kDa

packaging

pkg of 160 nmol

storage condition

avoid repeated freeze/thaw cycles

concentration

>0.02 mg/mL

NCBI accession no.

NM_003532

UniProt accession no.

P68431

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HIST1H3E(8353)

Application

Study enzyme kinetics, and screen small molecular inhibitors of Histone 3, K4,K9, methyltransferases for drug discovery and HTS applications

Physical form

Supplied as water solution, 800 μM

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube to recover full content of the tube. Aliquot into single use aliquots. Store remaining product in aliquots at -70°C. Note: Avoid freeze/thaw cycles.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SRP0159-160NMOL:

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Certificates of Analysis (COA)

Lot/Batch Number
5201050112
52010001001
5201001001

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Histone

PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state.
Loyola A
Molecular Cell, 24(2), 309-316 (2006)
The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin.
Conn KL
PLoS Pathogens, 9(10), e1003695-e1003695 (2013)
The program for processing newly synthesized histones H3.1 and H4.
Campos EI
Nature Structural and Molecular Biology, 17(11), 1343-1351 (2010)
Hideaki Tagami et al.
Cell, 116(1), 51-61 (2004-01-14)
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
Ahmad K and Henikoff S
Molecular Cell, 9(6), 1191-1200 (2002)
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