SML3989
DRP1 Inhibitor, MIDI
≥98% (HPLC)
Synonym(s):
1,1′-(1,4-Phenylene)bis[3-(3-pyridinyl)-2-propen-1-one], MIDI
About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 0.5 mg/mL, clear (Warmed)
storage temp.
room temp
SMILES string
O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2
InChI key
IOESTAVFGVAMRH-YDWXAUTNSA-N
Biochem/physiol Actions
DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
SML3989-BULK:
SML3989-VAR:
SML3989-5MG:
SML3989-25MG:
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