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Safety Information

SML3786

Sigma-Aldrich

Polaprezinc

≥97% (Zinc Elemental Analysis)

Synonym(s):

(N-(3-aminopropionyl)-L-histidinato zinc, N-β-Alanyl- L-histidine zinc complex, Zinc L-carnosine, beta-alanyl-L-histidinato zinc

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About This Item

Empirical Formula (Hill Notation):
C9H12N4O3Zn
CAS Number:
107667-60-7
Molecular Weight:
289.61
UNSPSC Code:
12352200
NACRES:
NA.21
Pricing and availability is not currently available.

Quality Level

100

Assay

≥97% (Zinc Elemental Analysis)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

[Zn]1N([C@H](C(=O)O1)Cc2[nH]cnc2)C(=O)CCN

InChI key

IGXZLYMCFZHNKW-FJXQXJEOSA-L

Biochem/physiol Actions

Mucosal protective agent that exhibits ROS-quenching activities; stimulates Hsp70 expression
Polaprezinc is an orally available Zinc L-carnosine complex. It is a mucosal protective agent that exhibits ROS-quenching activities, which promotes the repair of damaged tissues. Polaprezinc exerts cytoprotection through stimulation of Hsp70 expression that prevents the development of inflammatory process in the large intestinal mucosa. It is approved in Japan and Korea for treatment of gastric ulcers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3786-VAR:
SML3786-50MG:
SML3786-BULK:
SML3786-10MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000306948
0000306947
0000244441

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Role of nutritional zinc in the prevention of osteoporosis
Molecular and Cellular Biochemistry, 338(1-2), 241-254 (2010)
Antioxidant, Anti-inflammatory, and Genomic Stability Enhancement Effects of Zinc l-carnosine: A Potential Cancer Chemopreventive Agent
Nutrition and Cancer, 69(2), 201-210 (2017)
Drug repositioning of polaprezinc for bone fracture healing
Communications biology, 5(1), 462-462 (2022)

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