Skip to Content
Merck
All Photos(1)

Documents

Safety Information

SML3400

Sigma-Aldrich

NVS-ZP7-7

≥98% (HPLC)

Synonym(s):

(S)-3,4-Difluoro-N-(1-(2′-oxo-2′,3′-dihydro-1′H-spiro[piperidine-4,4′-quinazoline]-1-yl)-3-phenylpropan-2-yl)benzamide, NVP-LMU348

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C28H28F2N4O2
Molecular Weight:
490.54
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

NVS-ZP7-7 is potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-7 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter that increases ER zinc levels. It appears that inhibition of ZIP7 provided significant protection against ferroptosis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3400-25MG:
SML3400-VAR:
SML3400-BULK:
SML3400-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Discovery of a ZIP7 inhibitor from a Notch pathway screen
Nature Chemical Biology, 15(2), 179-188 (2019)
Po-Han Chen et al.
Cell death & disease, 12(2), 198-198 (2021-02-21)
Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses and characterized by extensive lipid peroxidation and membrane damages. The name of ferroptosis indicates that the ferroptotic death process depends on iron, but not other metals

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service