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SML2174

Sigma-Aldrich

MS012

≥98% (HPLC)

Synonym(s):

N2-Hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine

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5 MG
¥15,560
25 MG
¥62,480

¥15,560

Estimated to ship onApril 20, 2025

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5 MG
¥15,560
25 MG
¥62,480

About This Item

Empirical Formula (Hill Notation):
C22H35N5O2
CAS Number:
2089617-83-2
Molecular Weight:
401.55
UNSPSC Code:
12352200
NACRES:
NA.77

¥15,560

Estimated to ship onApril 20, 2025

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CN(CC1)CCC1NC2=C3C(C=C(OC)C(OC)=C3)=NC(NCCCCCC)=N2

InChI

1S/C22H35N5O2/c1-5-6-7-8-11-23-22-25-18-15-20(29-4)19(28-3)14-17(18)21(26-22)24-16-9-12-27(2)13-10-16/h14-16H,5-13H2,1-4H3,(H2,23,24,25,26)

InChI key

ZYNUWSFRZCRKSN-UHFFFAOYSA-N

Biochem/physiol Actions

G9a-like Protein (GLP) lysine methyl transferase Inhibitor
MS012 is a selective G9a-like Protein (GLP) lysine methyl transferase (PKMT) inhibitor with an IC50 value of 7 nM and over 140-fold selectivity for GLP over G9a and other methyl transferases tested.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2174-25MG:
SML2174-BULK:
SML2174-5MG:
SML2174-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000044917
0000044918
0000037024

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Yan Xiong et al.
Bioorganic & medicinal chemistry, 25(16), 4414-4423 (2017-07-01)
Given the high homology between the protein lysine methyltransferases G9a-like protein (GLP) and G9a, it has been challenging to develop potent and selective inhibitors for either enzyme. Recently, we reported two quinazoline compounds, MS0124 and MS012, as GLP selective inhibitors.
Yan Xiong et al.
Journal of medicinal chemistry, 60(5), 1876-1891 (2017-01-31)
G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone

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