Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

SML1966

Sigma-Aldrich

SK609 hydrochloride

≥98% (HPLC)

Synonym(s):

4-(2-Chlorophenyl)butan-2-amine hydrochloride, ES609, SK609•HCl

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H14ClN · HCl
CAS Number:
1092797-77-7
Molecular Weight:
220.14
UNSPSC Code:
12352202
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light
under inert gas

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

SK609 (ES609) is a Dopamine D3 receptor (D3R) selective agonist with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation. SK609 has been shown to reverse akinesia and reduce L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson′s desease. It does not induce desensitization of D3R.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1966-VAR:
SML1966-BULK:
SML1966-25MG:
SML1966-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sherise L Simms et al.
Neuropharmacology, 100, 106-115 (2015-04-22)
Synthetic dopaminergic agents have found utility in treating neurological and neuropsychiatric disorders since the beginning of 19th century. The discovery of Levodopa (l-dopa) to effectively treat motor symptoms of Parkinson's disease (PD) revolutionized the therapy and remains a gold standard
Wei Xu et al.
ACS chemical neuroscience, 8(3), 486-500 (2016-11-02)
Dopamine receptors play an integral role in controlling brain physiology. Importantly, subtype selective agonists and antagonists of dopamine receptors with biased signaling properties have been successful in treating psychiatric disorders with a low incidence of side effects. To this end

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service