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Safety Information

P215

Sigma-Aldrich

PD 98,059

solid

Synonym(s):

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059

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1 MG
¥27,500
5 MG
¥40,200

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1 MG
¥27,500
5 MG
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About This Item

Empirical Formula (Hill Notation):
C16H13NO3
CAS Number:
167869-21-8
Molecular Weight:
267.28
MDL number:
MFCD00671789
UNSPSC Code:
12352200
PubChem Substance ID:
24278666
NACRES:
NA.77

¥27,500

Available to ship onApril 07, 2025Details

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form

solid

color

yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

Gene Information

human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

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Application

PD 98,059 has been used:
  • in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors[1]
  • in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown[2]
  • in culture medium for cell migration assay[3]

Biochem/physiol Actions

PD 98,059 is a flavonoid[4] and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock.[5] It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.[6]

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P215-5MG:
P215-1MG:
P215-VAR:
P215-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT9208
MKCN2664
MKCF6098
MKCD4236
MKBX1068V

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Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)
Lingling Zhang et al.
European journal of pharmacology, 792, 15-25 (2016-11-05)
Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been
D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression
Zeng C, et al.
Journal of Hypertension, 27(5), 1033-1033 (2009)
PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression
Maugeri G, et al.
Frontiers in Pharmacology, 7, 139-139 (2016)
D T Dudley et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(17), 7686-7689 (1995-08-15)
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs). We have identified a synthetic inhibitor of the MAPK pathway. PD
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