Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML0629

Sigma-Aldrich

Mitochondrial Fusion Promoter M1

≥95% (HPLC)

Synonym(s):

(E)-4-Chloro-2-(1-(2-(2,4,6-trichlorophenyl)hydrazono)ethyl)phenol, 1-(5-Chloro-2-hydroxyphenyl)-ethanone 2-(2,4,6-trichlorophenyl)hydrazone

Sign Into View Organizational & Contract Pricing

Select a Size

25 MG
¥38,100

¥38,100

Available to ship onApril 14, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
25 MG
¥38,100

About This Item

Empirical Formula (Hill Notation):
C14H10Cl4N2O
CAS Number:
219315-22-7
Molecular Weight:
364.05
UNSPSC Code:
12352200
NACRES:
NA.77

¥38,100

Available to ship onApril 14, 2025Details

Request a Bulk Order

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

Clc1c(c(cc(c1)Cl)Cl)NNC(=C)c2c(ccc(c2)Cl)O

InChI key

WMAGOVJOXMBLHY-UHFFFAOYSA-N

Application

Mitochondrial Fusion Promoter M1 has been used as a fusion promoter:
  • to study its effects on peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α expression in breast cancer cells[1]
  • to study the link between nucleoside diphosphate kinase 3 (NME3)-regulated mitochondrial fluctuations and stability of genome in NME3 knockdown cells[2]
  • to study its effects on mitochondrial fusion in neuronal cells[3]

Biochem/physiol Actions

Mitochondrial Fusion Promoter M1 is a cell permeable hydrazone that enhances mitochondrial fusion.
Mitochondrial Fusion Promoter M1 is a cell permeable hydrazone that enhances mitochondrial fusion. M1 protects cells from mitochondrial fragmentation associated cell death. Mitochondrial Fusion Promoter M1 does not interfere with endoplasmic reticula (ER) and lysosomes morphology.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0629-BULK:
SML0629-VAR:
SML0629-25MG:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000396294
0000396294
0000264685
0000239580
0000239580

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kehan Ren et al.
Experimental cell research, 400(1), 112493-112493 (2021-01-25)
Most cancer deaths are due to the colonization of tumor cells in distant organs. More evidence indicates that overexpression of RACGAP1 plays a critical role in cancer metastasis. However, the underlying mechanism still remains poorly understood. Here we found that
Ryohei Iwata et al.
Science (New York, N.Y.), 369(6505), 858-862 (2020-08-15)
The conversion of neural stem cells into neurons is associated with the remodeling of organelles, but whether and how this is causally linked to fate change is poorly understood. We examined and manipulated mitochondrial dynamics during mouse and human cortical
Minjie Shen et al.
Nature neuroscience, 22(3), 386-400 (2019-02-12)
Fragile X syndrome results from a loss of the RNA-binding protein fragile X mental retardation protein (FMRP). How FMRP regulates neuronal development and function remains unclear. Here we show that FMRP-deficient immature neurons exhibit impaired dendritic maturation, altered expression of
Chih-Wei Chen et al.
International journal of molecular sciences, 21(14) (2020-07-28)
NME3 is a member of the nucleoside diphosphate kinase (NDPK) family that binds to the mitochondrial outer membrane to stimulate mitochondrial fusion. In this study, we showed that NME3 knockdown delayed DNA repair without reducing the cellular levels of nucleotide

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service