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SCP0247

Sigma-Aldrich

Factor VIIa substrate

≥95% (HPLC), lyophilized

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About This Item

Empirical Formula (Hill Notation):
C30H42N7O7S1
Molecular Weight:
644.76
UNSPSC Code:
12352204
NACRES:
NA.32

product name

Factor VIIa substrate,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥72%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

MeSO2-Cha-Abu-Arg-AFC

Application

Factor VIIa is a serine protease involved in the blood coagulation cascade. The activity of Factor VIIa can be assayed with chromogenic substrate MeSO2-Cha-Abu-Arg-pNA or the flourogenic substrate MeSO2-Cha-Abu-Arg-AFC.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SCP0247-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Flora Peyvandi et al.
Thrombosis and haemostasis, 88(5), 750-755 (2002-11-13)
Factor VII (FVII) requires the cleavage of an internal peptide bond and the association with tissue factor (TF) to attain its fully active FVIIa conformation. This event alone leaves FVIIa in a zymogen-like state of relatively low specific activity. The
Giuseppe Lippi et al.
Seminars in thrombosis and hemostasis, 35(1), 9-22 (2009-03-25)
Hemostasis is traditionally defined as the physiologic process whereby bleeding is antagonized and possibly stopped to minimize blood loss. The first medical description of the clinical and inherited features of hemostasis can be dated back more than 1000 years, when

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