Skip to Content
Merck
All Photos(1)

Documents

Safety Information

S9564

Sigma-Aldrich

Amyloid Precursor Protein α, Secreted human

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

Synonym(s):

sAPPα

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD03454663
UNSPSC Code:
12352202
NACRES:
NA.32

recombinant

expressed in E. coli (N-terminal histidine tagged)

Quality Level

200

Assay

>90% (SDS-PAGE)

form

buffered aqueous solution

mol wt

~100 kDa by SDS-PAGE

UniProt accession no.

P05067

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... APP(351)

General description

The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.

Application

Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.

Physical form

Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.

Preparation Note

Expressed as a soluble protein and purified under non-denaturing conditions.

Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

S9564-25UG-PW:
S9564-BULK:
S9564-25UG:
S9564-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Luo, J.J., et al.
Neuroscience Research, 63, 410-410 (2001)
In vivo BACE1 inhibition leads to brain A?
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
Sethu Sankaranarayanan
American Society for Engineering Education (2018)
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsa
Frontiers in Molecular Neuroscience (2017)
Dementia: New Insights for the Healthcare Professional, 478-478 (2013)
C U Pietrzik et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1770-1775 (1998-03-21)
In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service