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L9125

Sigma-Aldrich

L-Leucine-p-nitroanilide

leucine aminopeptidase substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

L-Leucine-4-nitroanilide

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250 MG
¥10,500
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¥18,400
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¥28,600
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¥97,500

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250 MG
¥10,500
500 MG
¥18,400
1 G
¥28,600
5 G
¥97,500

About This Item

Empirical Formula (Hill Notation):
C12H17N3O3
CAS Number:
4178-93-2
Molecular Weight:
251.28
Beilstein:
2218433
EC Number:
224-047-3
MDL number:
MFCD00063681
UNSPSC Code:
12352204
PubChem Substance ID:
24896516
NACRES:
NA.32

¥10,500

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Product Name

L-Leucine-p-nitroanilide, leucine aminopeptidase substrate

Assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C12H17N3O3/c1-8(2)7-11(13)12(16)14-9-3-5-10(6-4-9)15(17)18/h3-6,8,11H,7,13H2,1-2H3,(H,14,16)/t11-/m0/s1

InChI key

AXZJHDNQDSVIDR-NSHDSACASA-N

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Application

L-Leucine-p-nitroanilide has been used as substrate
  • for the determination of intestinal leucine aminopeptidase activity of juvenile rainbow trout (Oncorhynchus mykiss)[1]
  • in insulin-regulated aminopeptidase inhibition assay[2]
  • for determining exopeptidase activity[3]

Substrates

Substrate for the colorimetric determination of leucine aminopeptidase.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L9125-1LSAMPLE:
L9125-250MG:
L9125-200L:
L9125-PROC:
L9125-BULK:
L9125-VAR:
L9125-500MG:
L9125-50L:
L9125-1G:
L9125-5G:

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Certificates of Analysis (COA)

Lot/Batch Number
0000393416
0000393822
0000361918
0000361916
0000361917

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Natasa Bozić et al.
Electrophoresis, 26(12), 2476-2480 (2005-05-28)
A general method for detecting leucyl aminopeptidase activity after native polyacrylamide gel electrophoresis (PAGE) in situ is described. The method is based on diazotization of p-nitroaniline, liberated in the polyacrylamide gel by leucyl aminopeptidase action on leucine-p-nitroanilide (LpNA) and subsequent
Reishi Toshiyama et al.
Oncogene, 38(2), 244-260 (2018-08-10)
Previous studies highlighted that aminopeptidase N (APN)/CD13 acts as a scavenger in the survival of hepatocellular carcinoma (HCC) stem cells by reducing reactive oxygen species (ROS) levels. Hence, it has been proposed that APN/CD13 inhibition can increase cellular ROS levels
Antioxidant response and body composition of whiteleg shrimp co-cultured with Nile tilapia in recirculating aquaculture
Sharawy ZZ, et al.
Aquaculture Environment Interactions, 9(3), 257-268 (2017)
Pablo Emiliano Cantón et al.
Frontiers in physiology, 10, 1553-1553 (2020-01-24)
Nezara viridula is a polyphagous stink bug that feeds on crops of economic importance such as corn, soybean and cotton. To increase understanding of the ability of this pest insect to feed on such diverse cropping systems, we analyzed the
C Toma et al.
Infection and immunity, 64(11), 4495-4500 (1996-11-01)
The structural gene for the Vibrio cholerae leucine aminopeptidase (lap) was cloned and sequenced. The cloned DNA fragment contained a 1,503-bp open reading frame potentially encoding a 501-amino-acid polypeptide with a calculated molecular mass of 54,442 Da. The deduced amino
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