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Safety Information

S4026

Sigma-Aldrich

Semustine

Synonym(s):

N-(2-Chloroethyl)-N′-(4-methylcyclohexyl)-N-nitrosourea, Methyl-CCNU

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About This Item

Empirical Formula (Hill Notation):
C10H18ClN3O2
CAS Number:
13909-09-6
Molecular Weight:
247.72
MDL number:
MFCD00133811
UNSPSC Code:
12352100
PubChem Substance ID:
24899584
NACRES:
NA.22
Pricing and availability is not currently available.

SMILES string

CC1CCC(CC1)NC(=O)N(CCCl)N=O

InChI

1S/C10H18ClN3O2/c1-8-2-4-9(5-3-8)12-10(15)14(13-16)7-6-11/h8-9H,2-7H2,1H3,(H,12,15)

InChI key

FVLVBPDQNARYJU-UHFFFAOYSA-N

Application

Commonly used in pharmacological studies involving:
  • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis
  • CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma
  • Investigations into its use for chemotherapy

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

S4026-VAR:
S4026-25MG:
S4026-250MG:
S4026-BULK:
S4026-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
091H0080

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1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (MeCCNU).
Report on carcinogens : carcinogen profiles, 10, 53-54 (2004-08-24)
Zhenyu Zhao et al.
Brain research bulletin, 86(3-4), 189-194 (2011-08-03)
The prognosis of glioblastoma (GBM) is poor. The therapeutic outcome of conventional surgical and adjuvant treatments remains unsatisfactory, and therefore individualized adjuvant chemotherapy has aroused more attention. Microarrays have been applied to study mechanism of GBM development and progression but
Andreas Meyer et al.
Acta oncologica (Stockholm, Sweden), 45(6), 728-735 (2006-08-30)
The aim of this retrospective analysis was to evaluate feasibility and effectiveness of definitive chemoradiotherapy without split-course technique in anal cancer patients. From 1993 to 2003, 81 patients were treated; 13 were excluded due to various chemotherapeutic regimes, thus 68
[Clinical significance of mustoforan in management of malignant glioma].
G L Kobiakov
Voprosy onkologii, 53(6), 724-729 (2008-04-18)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Report on carcinogens : carcinogen profiles, 11, III53-III53 (2004-01-01)
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