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Safety Information

C0400

Sigma-Aldrich

Carmustine

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

Synonym(s):

1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU

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¥12,950
100 MG
¥35,910

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Estimated to ship onMarch 29, 2025

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25 MG
¥12,950
100 MG
¥35,910

About This Item

Empirical Formula (Hill Notation):
C5H9Cl2N3O2
CAS Number:
154-93-8
Molecular Weight:
214.05
EC Number:
205-838-2
MDL number:
MFCD00057706
UNSPSC Code:
12352200
PubChem Substance ID:
24278289
NACRES:
NA.77

¥12,950

List Price¥18,500Save 30%

Estimated to ship onMarch 29, 2025

Request a Bulk Order

Product Name

Carmustine, ≥98%

Quality Level

200

Assay

≥98%

form

(Oily liquid to amorphous solid)

mp

30 °C (lit.)

solubility

ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow

originator

Bristol-Myers Squibb

storage temp.

−20°C

SMILES string

ClCCNC(=O)N(CCCl)N=O

InChI

1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChI key

DLGOEMSEDOSKAD-UHFFFAOYSA-N

Gene Information

human ... GSR(2936)

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General description

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.[1]

Application

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector.[2] It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.[3]

Biochem/physiol Actions

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks.[4] Effective against glioma and other solid tumors.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300,H350,H360

Precautionary Statements

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

C0400-BULK:
C0400-100MG:
C0400-VAR:
C0400-25MG:
C0400-25MG-PW:
C0400-100MG-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
0000415088
0000415088
0000224891
0000142953
0000139073

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Mapping the human kinome in response to DNA damage
Owusu M, et al.
Testing, 26(3), 555-563 (2019)
Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection
Olszko ME, et al
Gene Therapy, 22(7), 591-591 (2015)
John Blazeck et al.
Biotechnology journal, 5(7), 647-659 (2010-02-13)
The advent of high throughput genome-scale bioinformatics has led to an exponential increase in available cellular system data. Systems metabolic engineering attempts to use data-driven approaches--based on the data collected with high throughput technologies--to identify gene targets and optimize phenotypical
Ching-Hsiang Fan et al.
Biomaterials, 34(8), 2142-2155 (2012-12-19)
Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood-brain barrier (BBB)
16th Int?l. Sympos. High Voltage Eng (2016)
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