Skip to Content
Merck
All Photos(1)

Documents

Safety Information

P2745

Sigma-Aldrich

Protein Phosphatase Inhibitor 1 human

Synonym(s):

Inhibitor 1 human

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD01635659
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

>95% (SDS-PAGE)

form

solution

mol wt

~31 kDa
apparent mol wt ~27 kDa

UniProt accession no.

Q12972
Q13522

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PPP1R1A(5502) , PPP1R8(5511)

Looking for similar products? Visit Product Comparison Guide

Application

This protein phosphatase inhibitor 1 is suitable for use as a substrate to identify novel phosphatases and kinases that modulate protein phosphatase inhibitor 1 activity. This product is also suitable for use in affinity pull-down binding studies. Protein Phosphatase Inhibitor 1 human has been used as a component in the sucrose cell lysis buffer. It has also been used for intraperitoneal injection of mice prior to natterins or saline treatment in pharmacological intervention studies.

Biochem/physiol Actions

Intimately involved in glycogen metabolism as an inhibitor of phosphorylase phosphatase, the enzyme responsible for conversion of phosphorylase b to phosphorylase a. Inhibition is invoked only upon phosphorylation by a cAMP-dependent protein kinase.

Physical form

Supplied as a solution in 50 mM Tris-HCl, pH 7.0, containing 0.1 mM PMSF, 14 mM 2-mercaptoethanol, and 10% glycerol

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

P2745-1UG-PW:
P2745-1UG:4548173289328
P2745-VAR:
P2745-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Inhibition of Inflammatory Changes in Human Myometrial Cells by Cell Penetrating Peptide and Small Molecule Inhibitors of NF kappaB
Gurney LRI, et al.
Frontiers in Immunology, 9, 2966-2966 (2018)
Zlatka Plavec et al.
Viruses, 14(9) (2022-09-24)
Severe acute respiratory syndrome coronavirus-2 is the causative agent of COVID-19. During the pandemic of 2019-2022, at least 500 million have been infected and over 6.3 million people have died from COVID-19. The virus is pleomorphic, and due to its
Xiaonan Liu et al.
Molecular systems biology, 17(11), e10396-e10396 (2021-10-29)
Treatment options for COVID-19, caused by SARS-CoV-2, remain limited. Understanding viral pathogenesis at the molecular level is critical to develop effective therapy. Some recent studies have explored SARS-CoV-2-host interactomes and provided great resources for understanding viral replication. However, host proteins
Furong Song et al.
International journal of molecular medicine, 46(3), 1135-1145 (2020-07-25)
Propofol is a commonly used drug for the induction and maintenance of anesthesia. Previous studies have reported that propofol is involved in the progression of numerous human cancer types, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms in HCC
Marcio Jose Ferreira et al.
Toxicon : official journal of the International Society on Toxinology, 87, 54-67 (2014-06-03)
Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in venules of mouse cremaster muscle using intravital microscopy. We reported that low doses of Natterins interfere with the cell

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service