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Safety Information

N7632

Sigma-Aldrich

N-Nitrosodiethanolamine

Synonym(s):

2,2′-(Nitrosoimino)bisethanol, N,N-Diethanolnitrosamine, Bis(2-hydroxyethyl)nitrosamine, NDELA

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About This Item

Empirical Formula (Hill Notation):
C4H10N2O3
CAS Number:
1116-54-7
Molecular Weight:
134.13
Beilstein:
1762620
MDL number:
MFCD00015522
UNSPSC Code:
12352116
PubChem Substance ID:
24897834
NACRES:
NA.25

form

liquid

impurities

≤10% Isopropanol

storage temp.

2-8°C

SMILES string

OCCN(N=O)CCO

InChI

1S/C4H10N2O3/c7-3-1-6(5-9)2-4-8/h7-8H,1-4H2

InChI key

YFCDLVPYFMHRQZ-UHFFFAOYSA-N

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Application


  • Changes in levels of N-nitrosamine formed from amine-containing compounds during chloramination via photocatalytic pretreatment with immobilized TiO(2): Effect of source water and pH.: In this study, NDELA is used as a standard to examine how the formation of nitrosamines, such as N-Nitrosodiethanolamine, is affected by different water sources and pH levels during water treatment processes (Seid et al., 2022).

  • Monitoring and risk assessment of hazardous chemicals in toy-slime and putty in the Netherlands.: This research focuses on the presence of N-Nitrosodiethanolamine in children′s toys, providing important data for consumer safety and regulatory standards (Braver et al., 2021).

  • On-line solid phase extraction-ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of N-nitrosodiethanolamine in baby shampoo.: Highlights the usage of N-Nitrosodiethanolamine as an analytical standard in application of advanced chromatographic techniques for detecting harmful substances in consumer products, ensuring product safety and regulatory compliance (Tada et al., 2021).

Pictograms

FlameHealth hazard
GHS02,GHS08

Signal Word

Danger

Hazard Statements

H225,H350

Hazard Classifications

Carc. 1B - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

52.9 °F

Flash Point(C)

11.6 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

N7632-BULK:
N7632-500MG:4548173357539
N7632-VAR:
N7632-5G:
N7632-1G:4548173357522

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M T Matyska et al.
Journal of chromatography. A, 887(1-2), 497-503 (2000-08-29)
The presence of the carcinogenic N-nitrosodiethanolamine (NDELA; CAS No. 1116-54-7) in cosmetic samples was determined using an etched, C18 modified capillary in the open-tubular capillary electrochromatography technique. A very simple extraction procedure leads to a sample matrix free from interferences.
U Harréus et al.
Laryngo- rhino- otologie, 78(4), 176-181 (1999-07-17)
In numerous epidemiologic studies, environmental and occupational substances such as sodium dichromate (Na2Cr2O7), benzo[a]pyren (B(a)P), and N'nitroso-diethanolamine (NDELA) have been shown to be of potential carcinogenic risk on human epithelial cells in the upper aerodigestive tract. Using the alkaline microgel
S Monarca et al.
Environmental health perspectives, 104(1), 78-82 (1996-01-01)
Biological monitoring of occupational hazards was performed in workers using cutting fluids containing N-nitrosodiethanolamine (NDELA). The study involved a group of 25 male subjects from some metal factories in central Italy who used cutting fluids with an NDELA content of
R Hasegawa et al.
Cancer letters, 123(2), 185-191 (1998-03-07)
Complete carcinogens must possess both initiating and promoting properties. Most N-nitroso compounds are mutagens and are considered to be initiators, but some are not mutagenic and yet are complete carcinogens. To investigate the two activities, brief treatments of male F344
C Thirunavukkarasu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 57(9), 416-421 (2003-12-04)
Selenium (Se), a dietary micronutrient, plays a vital role in cancer chemotherapy in many organs including the liver. We have studied the relationship between some minerals, which are essential in normal functioning of cells and anticancer effect of Se in
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