MAK244

Plasmin Activity Assay Kit (Fluorometric)

sufficient for 100 fluorometric tests

• Synonym(s): Plasmin Fluorometric Assay Kit
• UNSPSC Code: 12161503
• NACRES: NA.84

Properties

• detection method: fluorometric
• relevant disease(s): cancer; hematological disorder
• storage temp.: −20°C

Description

General description

Plasmin (EC 3.4.21.7) is a serine protease occurring in plasma as plasminogen. Upon activation via cleavage by plasminogen activators; plasmin solubilizes fibrin clots and activates and/or degrades compounds of the coagulation and complement systems. Plasminogen-Plasmin system has also been implicated in a wide variety of physiologic and pathologic processes, including tumor growth, invasion and metastasis.

Suitability

Suitable to determine the activity of pure plasmin and to detect the activity of plasmin in plasma.

Principle

The Plasmin Activity Assay Kit is based on the ability of plasmin to proteolytically cleave a synthetic substrate and release a fluorophore, AMC, which can be easily quantified by fluorescence microplate readers. This assay kit is simple, rapid, and can detect plasmin activity as low as 10 ng in a variety of samples.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2