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M6449

Sigma-Aldrich

MART-1 (26-35), Human

lyophilized powder

Synonym(s):

Antigen LB39-AA (26-35) (human), Antigen SK29-AA (26-35) (human), Melan-A Protein (26-35) (human), Melanoma Antigen Recognized By T-Cells 1 (26-35) (human)

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

form

lyophilized powder

Quality Level

200

color

white

solubility

water, double-distilled: soluble

storage temp.

−20°C

Amino Acid Sequence

Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

General description

The peptide represents amino acids 26-35 of MART-1 protein that is the melanoma antigen recognized by T cells. This peptide mimics the natural epitope that is presented by T cells in humans with reactivity to melanoma cells.
Melanoma-associated antigen recognized by T cells-1 (MART-1), also known as Melan-A, is encoded by the gene mapped to human chromosome 9p24.1. The encoded protein is a hydrophobic transmembrane protein. MART-1 is mainly expressed in skin and retinae melanocytes.

Biochem/physiol Actions

Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M6449-5MG:
M6449-1MG-PW:
M6449-BULK:
M6449-5MG-PW:
M6449-1MG:
M6449-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis
Guo R, et al.
International Journal of Clinical and Experimental Pathology, 7(1), 468-468 (2014)
María Marcela Barrio et al.
PloS one, 7(7), e40311-e40311 (2012-07-07)
Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells. They have been used in different clinical settings to vaccinate cancer patients. We have previously used gamma-irradiated MART-1 expressing melanoma cells as

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