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G6910

Supelco

Ginkgolide B from Ginkgo biloba leaves

≥90% (HPLC)

Synonym(s):

BN-52021

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About This Item

Empirical Formula (Hill Notation):
C20H24O10
CAS Number:
15291-77-7
Molecular Weight:
424.40
MDL number:
MFCD05662347
UNSPSC Code:
85151701
PubChem Substance ID:
24895280
NACRES:
NA.24

Assay

≥90% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@@]36[C@@H](O)C(=O)O[C@H]6O[C@@]4(C(=O)O5)[C@@]12O

InChI

1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10+,11+,15+,17+,18+,19-,20-/m1/s1

InChI key

SQOJOAFXDQDRGF-MMQTXUMRSA-N

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General description

Ginkgolide B from Ginkgo biloba leaves is a terpene lactone and one of the main molecular form of ginkgolides, present in Ginkgo biloba leaves. It is widely used to treat peripheral and cerebral circulation disorders.

Application

Ginkgolide B from Ginkgo biloba leaves is used as an analytical reference standard:
  • For the chromatographic separation of the analyte in Ginkgo biloba leaves extract and to study the antimicrobial activity exerted on a variety of Gram-positive and -negative bacteria and yeasts.
  • For the determination of the analyte in Ginkgo biloba L. phytopharmaceuticals using high-performance liquid chromatography technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Primary constituent of Ginkgo biloba. Potential anticancer agent and neuroprotective.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G6910-VAR:
G6910-10MG:
G6910-BULK:
G6910-50MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Antimicrobial investigation of semi-purified fractions of Ginkgo biloba leaves
Mazzanti.G, et al.
Journal of Ethnopharmacology, 71(1-2), 83-88 (2005)
Christoph A Reichel et al.
PloS one, 6(2), e17229-e17229 (2011-03-03)
Clinical trials revealed beneficial effects of the broad-spectrum serine protease inhibitor aprotinin on the prevention of ischemia-reperfusion (I/R) injury. The underlying mechanisms remained largely unclear. Using in vivo microscopy on the cremaster muscle of male C57BL/6 mice, aprotinin as well
Yuan Yuan et al.
Journal of chromatographic science, 51(3), 266-272 (2012-08-31)
A sensitive, simple and rapid liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of ginkgolide B (GB) and the prodrug of ginkgolide B (PGB) in rat plasma and brain tissue. Detection was performed on a
Vyala Hanumanthareddy Chaithra et al.
Journal of lipid research, 59(11), 2063-2074 (2018-08-25)
Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant amounts of the less potent PAF analogue acyl-PAF, which competes for PAF-R. Both PAF species
Shi-hai Xia et al.
Chinese medical journal, 120(10), 922-928 (2007-06-05)
To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating
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