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Safety Information

G0668

Sigma-Aldrich

GW2974

≥98% (HPLC), solid

Synonym(s):

N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido­[3,4-d]­pyrimidine-4,6-diamine

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50 MG
¥30,700
250 MG
¥129,000

¥30,700

Estimated to ship onMay 29, 2025

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50 MG
¥30,700
250 MG
¥129,000

About This Item

Empirical Formula (Hill Notation):
C23H21N7
CAS Number:
202272-68-2
Molecular Weight:
395.46
MDL number:
MFCD04974495
UNSPSC Code:
51111800
PubChem Substance ID:
24278451
NACRES:
NA.77

¥30,700

Estimated to ship onMay 29, 2025

Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: ≥20 mg/mL

originator

GlaxoSmithKline

SMILES string

CN(C)c1cc2c(Nc3ccc4n(Cc5ccccc5)ncc4c3)ncnc2cn1

InChI

1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28)

InChI key

DYYZXRCFCVDSKD-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956) , ERBB2(2064)

Biochem/physiol Actions

Potent and selective dual inhibitor of EGFR (IC50 = 0.016 mM) and ErbB-2 receptor tyrosine kinase.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G0668-VAR:
G0668-BULK:
G0668-50MG:
G0668-250MG:

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Certificates of Analysis (COA)

Lot/Batch Number
019K4612
019K4610
012K47051
012K4705

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S Agarwal et al.
British journal of cancer, 100(6), 941-949 (2009-02-26)
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Molecular biology of the cell, 22(8), 1121-1134 (2011-02-18)
Desmocollin-2 (Dsc2) and desmoglein-2 (Dsg2) are transmembrane cell adhesion proteins of desmosomes. Reduced expression of Dsc2 has been reported in colorectal carcinomas, suggesting that Dsc2 may play a role in the development and/or progression of colorectal cancer. However, no studies
Hauke Busch et al.
Molecular systems biology, 4, 199-199 (2008-07-03)
Translation of large-scale data into a coherent model that allows one to simulate, predict and control cellular behavior is far from being resolved. Assuming that long-term cellular behavior is reflected in the gene expression kinetics, we infer a dynamic gene

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