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C6241

Sigma-Aldrich

Charcoal, Dextran Coated

Synonym(s):

Dextran coated charcoal

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About This Item

EC Number:
231-153-3
UNSPSC Code:
12141908
NACRES:
NC.07

form

powder

General description

Charcoal, Dextran Coated is made from acid washed charcoal powder and dextran, molecular weight 64-76kDa, combined in a 10:1 (w/w) ratio.

Application

Charcoal, Dextran Coated has been used:
  • as a supplement in cell culture media to test the functioning of androgen receptor
  • in the procedure of melatonin radioimmunoassay
  • for the preparation of steroid-free human serum
  • to reduce the creatinine level in untreated serum.

Biochem/physiol Actions

The use of dextran-coated charcoal makes the immunoassay of insulin in biological fluids simpler and more rapid. In theory, the charcoal coated with dextran will adsorb the free hormone and leave hormones that are bound to a carrier (or antibody). Dextran coated charcoal is used to strip hormones from serum instead of charcoal alone, because there is less loss of protein using dextran coated charcoal.

Other Notes

Dry preparation of dextran-treated charcoal

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C6241-5G:
C6241-BULK:
C6241-VAR:
C6241-20G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

C7606

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Multisteroid LC-MS/MS assay for glucocorticoids and androgens, and its application in Addison's disease.
Methlie P
Endocrine Connections (2013)
Shih-Hsing Leir et al.
Cell and tissue research, 381(2), 327-336 (2020-05-08)
Organoid cultures derived from primary human tissues facilitate the study of disease processes and the development of new therapeutics. Most men with cystic fibrosis (CF) are infertile due to defects in the epididymis and vas deferens; however, the causative mechanisms
Liang Shi et al.
Cell death & disease, 8(11), e3171-e3171 (2017-11-17)
Hepatocellular carcinoma (HCC) is a heterogeneous malignancy as a result of complex genetic and epigenetic alterations. HCC is characterized by a clear gender disparity for which there is lack of a clear mechanistic understanding. Androgen receptor (AR) is thought to
Modern Methods of Steroid Analysis (2012)
Coated charcoal immunoassay of insulin.
Herbert V
The Journal of Clinical Endocrinology and Metabolism, 25, 1375-1384 (1965)
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