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C6239

Sigma-Aldrich

Cinalukast

~98% (HPLC)

Synonym(s):

(E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid, Ro 24-5913

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About This Item

Empirical Formula (Hill Notation):
C23H28N2O3S
CAS Number:
128312-51-6
Molecular Weight:
412.55
MDL number:
MFCD00864778
UNSPSC Code:
12352202
PubChem Substance ID:
24724447
NACRES:
NA.77

Assay

~98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >10 mg/mL
H2O: insoluble

originator

Roche

storage temp.

2-8°C

SMILES string

CCC(CC)(CC(=O)Nc1cccc(\C=C\c2nc(cs2)C3CCC3)c1)C(O)=O

InChI

1S/C23H28N2O3S/c1-3-23(4-2,22(27)28)14-20(26)24-18-10-5-7-16(13-18)11-12-21-25-19(15-29-21)17-8-6-9-17/h5,7,10-13,15,17H,3-4,6,8-9,14H2,1-2H3,(H,24,26)(H,27,28)/b12-11+

InChI key

BZMKNPGKXJAIDV-VAWYXSNFSA-N

Gene Information

human ... CYSLTR1(10800)

Biochem/physiol Actions

Specific CysLT1 leukotriene receptor antagonist.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C6239-BULK:
C6239-25MG:
C6239-5MG:
C6239-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation.
A F Welton et al.
Annals of the New York Academy of Sciences, 744, 274-288 (1994-11-15)
Michael Föller et al.
European journal of clinical investigation, 40(6), 534-540 (2010-05-12)
Fever and hyperthermia are frequently associated with anaemia. Under most clinical conditions, they are considered to be two mutually independent clinical consequences of a common cause. The present study explored the possibility that anaemia results from temperature-sensitive suicidal erythrocyte death
H Maehr et al.
Bioorganic & medicinal chemistry, 5(3), 493-496 (1997-03-01)
Structure optimization of the leukotriene D4 antagonist Ro24-5913 was attempted by combinatorial chemistry. Three segments in its N-succinyl-3-(2-thiazolylethenyl)anilide skeleton, designated as A, B, and C coincided with the thiazolyl, aniline, and N-acyl moieties, respectively, and were selected for variations in
G E Rovati et al.
Biochemical pharmacology, 44(7), 1411-1415 (1992-10-06)
We have identified and characterized two different subclasses of binding site for the novel peptido-leukotriene (LT) antagonist, [3H]ICI 198,615, in membranes from human lung parenchyma using a receptor-ligand assay. This novel compound is representative of a new class of LT
E Adelroth et al.
The Journal of allergy and clinical immunology, 99(2), 210-215 (1997-02-01)
The degree and duration of protection against exercise-induced bronchoconstriction afforded by three doses of a specific leukotriene D4 receptor antagonist, cinalukast, were assessed after an initial dosing and after 1 week of therapy. A placebo-controlled crossover study was performed in
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