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Safety Information

1.06398

SAFC

Sodium carbonate

anhydrous, EMPROVE® ESSENTIAL, Ph. Eur., BP, ChP, JP, NF

Pharma Manufacturing

Synonym(s):

anhydrous soda, Calcined soda, Carbonic acid disodium salt, Soda ash

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About This Item

Linear Formula:
Na2CO3
CAS Number:
497-19-8
Molecular Weight:
105.99
Beilstein:
4154566
MDL number:
MFCD00003494
UNSPSC Code:
12352302
EC Index Number:
207-838-8

Agency

BP
ChP
JP
NF
Ph. Eur.

Quality Level

500

product line

EMPROVE® ESSENTIAL

form

solid

pH

11.16 (25 °C, 4 g/L in H2O)

mp

851 °C (lit.)

solubility

212.5 g/L

density

2.53 g/cm3 at 20 °C

application(s)

liquid formulation
pharmaceutical
solid formulation

storage temp.

2-25°C

SMILES string

O=C(O[Na])O[Na]

InChI

1S/CH2O3.2Na/c2-1(3)4;;/h(H2,2,3,4);;/q;2*+1/p-2

InChI key

CDBYLPFSWZWCQE-UHFFFAOYSA-L

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Sodium carbonate is a commonly used ingredient in both food and pharmaceutics. In pharmaceutical applications, sodium carbonate is used as pH adjuster, or a source of carbon dioxide in oral formulations such as effervescent tablets or granules.

Biochem/physiol Actions

Buffer component, may be used for the removal of peripheral membrane proteins.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

CO1E1063981000:
1063984025:
1063987777:
1063980000:
1063980403:
1063989999:
1063989013:
CO1I1063985000:
1063988889:
1063984100:
CO1E1063989029:
1063983010:
CO1I1063981000:
1063989500:
1063989052:
1063981000:
1063985000BWT:
1063985000:
1063989029:
1063980001:
1063989029BWT:
CO1E1063985000:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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