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Key Documents

Safety Information

L040050

Sigma-Aldrich

Cap A

configured for (ÄKTA® and OligoPilot®)

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2.5 L
¥77,200

¥77,200

Available to ship onApril 25, 2025Details

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2.5 L
¥77,200

About This Item

UNSPSC Code:
12352200
NACRES:
NA.21

¥77,200

Available to ship onApril 25, 2025Details

Request a Bulk Order

type

for DNA synthesis

Quality Level

200

product line

Proligo Reagents

form

liquid

storage condition

dry at room temperature

impurities

≤100 ppm water content (Karl Fischer)

color

clear

suitability

conforms to structure (GC, Formulation)

compatibility

configured for (ÄKTA® and OligoPilot®)

storage temp.

room temp

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Application

Cap A solution is used after the phosphoramidite reaction/coupling step. This solution aborts chains bearing unreacted 5′hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps.

Preparation Note

Acetonitrile / N-Methylimidazole 8/2 (v/v)

Other Notes

Cap A solution, containing acetonitrile (ACN) and N-methylimidazole (NMI), is mixed in situ with Cap B1 and Cap B2 solution during the capping (acetylation) reaction. Pyridine is applied as a mild base while NMI provides a powerful acylation catalyst.

Legal Information

OligoPilot is a registered trademark of Cytiva
ÄKTA is a registered trademark of Cytiva

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F

Flash Point(C)

2 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

L040050-6X450ML:
L040050-500ML:
L040050-15L:
L040050-2.5L:4548173342092

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Certificates of Analysis (COA)

Lot/Batch Number
HMBK5937
HMBK5741
HMBK5731
HMBK4963
HMBK4622

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