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Safety Information

57865

Sigma-Aldrich

4-Nitrophenyl iodoacetate

≥99.0%

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About This Item

Empirical Formula (Hill Notation):
C8H6INO4
CAS Number:
31252-85-4
Molecular Weight:
307.04
Beilstein:
1970746
EC Number:
250-536-6
MDL number:
MFCD00042813
UNSPSC Code:
12352100
PubChem Substance ID:
57651634
NACRES:
NA.22

Assay

≥99.0%

mp

79-82 °C

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(OC(=O)CI)cc1

InChI

1S/C8H6INO4/c9-5-8(11)14-7-3-1-6(2-4-7)10(12)13/h1-4H,5H2

InChI key

GERXSZLDSOPHJV-UHFFFAOYSA-N

Other Notes

For introducing the iodoacetyl group in peptides[1]; Synthesis of N-methyl iodoacetamide[2]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

57865-25G-F:
57865-5G-F:4548173995175
57865-VAR-F:
57865-BULK-F:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCC0072
BCBV9050
BCBK1446V
BCBQ2046V
BCBN2264V

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K Sutoh et al.
Biochemistry, 27(8), 2964-2969 (1988-04-19)
Subfragment 1 (S1) prepared from rabbit skeletal muscle myosin was digested with trypsin to cleave the 95K heavy chain into three pieces, i.e., the 23K, 50K, and 20K fragments. The trypsin-treated S1 was then cross-linked with p-nitrophenyl iodoacetate. The cross-linker
U Ramseier et al.
Analytical biochemistry, 221(2), 231-233 (1994-09-01)
Cysteine residues derivatized with N-methyl iodoacetamide (MIAA) can be analyzed by the Edman sequencing with a high degree of reliability. By HPLC, the phenylthiohydantoin (PTH) derivative of MIAA-modified cysteine eluted between dimethylphenylthiourea and PTH-Ala--a wide gap which is not occupied
T Hiratsuka
Biochemistry, 26(11), 3168-3173 (1987-06-02)
When myosin subfragment 1 (S-1) reacts with the bifunctional reagents with cross-linking spans of 3-4.5 A, p-nitrophenyl iodoacetate and p-nitrophenyl bromoacetate, the 20-kilodalton (20-kDa) segment of the heavy chain is cross-linked to the 26-kDa segment via the reactive thiol SH2.
Synthesis and characterization of two fluorescent sulfhydryl reagents.
E N Hudson et al.
Biochemistry, 12(21), 4154-4161 (1973-10-09)
Ya Zhang et al.
International journal of nanomedicine, 7, 1015-1022 (2012-03-10)
Polymersomes are nanosized vesicles formed from amphiphilic block copolymers, and have been identified as potential drug delivery vehicles to the inner ear. The aim of this study was to provide targeting to specific cells within the inner ear by functionalizing

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