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407925

Sigma-Aldrich

4-Chloro-3-nitrobenzoyl chloride

98%

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About This Item

Linear Formula:
ClC6H3(NO2)COCl
CAS Number:
38818-50-7
Molecular Weight:
220.01
EC Number:
254-133-6
MDL number:
MFCD00035743
UNSPSC Code:
12352100
PubChem Substance ID:
24865495

Assay

98%

mp

47-54 °C (lit.)

functional group

acyl chloride
chloro
nitro

SMILES string

[O-][N+](=O)c1cc(ccc1Cl)C(Cl)=O

InChI

1S/C7H3Cl2NO3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H

InChI key

IWLGXPWQZDOMSB-UHFFFAOYSA-N

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General description

4-Chloro-3-nitrobenzoyl chloride is an acid halide.

Application

4-Chloro-3-nitrobenzoyl chloride may be employed as acylation reagent for the Friedel-Crafts acylation of activated benzenes such as anisole, veratrole and 1,4-dimethoxybenzene. It may be employed for the synthesis of 4-chloro-4-methoxy-3-nitrobenzophenone. It may be employed as acylation reagent for the acylation reaction of the deactivated amines (2- aminopyrimidine, aminopyrazine).

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

407925-25G:
407925-BULK:
407925-100G:
407925-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
STBL1858
STBJ2035
STBF9385V
STBF8173V
STBF7321V

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Insights into the N,N-diacylation reaction of 2-aminopyrimidines and deactivated anilines: an alternative N-monoacylation reaction.
Theodorou V, et al.
ARKIVOC (Gainesville, FL, United States), 4, 11-23 (2014)
Tzvetomira Tzanova et al.
European journal of medicinal chemistry, 44(6), 2724-2730 (2008-10-28)
Considering that oxidative stress is strongly implicated in the toxicity of chemotherapy, much effort is focused on the research of diverse antioxidants as protective agents. An efficient synthesis of three novel benzophenones containing 1,3-thiazol moiety (6a-c) is described. Their antioxidant

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