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144436

Sigma-Aldrich

Isobutyramide

99%

Synonym(s):

2-Methylpropionamide

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25 G
¥13,200
100 G
¥21,500

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25 G
¥13,200
100 G
¥21,500

About This Item

Linear Formula:
(CH3)2CHCONH2
CAS Number:
563-83-7
Molecular Weight:
87.12
EC Number:
209-265-9
MDL number:
MFCD00008019
UNSPSC Code:
12352100
PubChem Substance ID:
24848653
NACRES:
NA.22

¥13,200

Available to ship onApril 21, 2025Details

Request a Bulk Order

Quality Level

100

Assay

99%

form

solid

bp

216-220 °C (lit.)

mp

127-131 °C (lit.)

density

1.013 g/mL at 25 °C (lit.)

functional group

amide

SMILES string

CC(C)C(N)=O

InChI

1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)

InChI key

WFKAJVHLWXSISD-UHFFFAOYSA-N

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Application

Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules[1].

Biochem/physiol Actions

Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene[2]. It is useful in the treatment of β-thalassemia and sickle cell disease[2].

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

144436-BULK:
144436-100G:
144436-25G:
144436-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF2764V
WXBF0941V
MKCR6654
WXBD7797V
WXBD4954V

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Damien Mertz et al.
ACS nano, 6(9), 7584-7594 (2012-09-07)
We report the sequential assembly of proteins via the alternating physical adsorption of human serum albumin (HSA) and chemical grafting with isobutyramide (IBAM) or bromoisobutyramide (BrIBAM) groups. This approach, performed on silica template particles, leads to the formation of noncovalent
M J Haas et al.
Journal of molecular endocrinology, 25(1), 129-139 (2000-07-29)
To determine if ketoacidosis contributes to reduced apolipoprotein A1 (apoA1) expression in insulin-deficient diabetic rats, we examined the regulation of apoA1 gene expression in response to changes in ambient pH or ketone body concentrations. Hepatic apoAI mRNA levels were reduced
L Hemmingsen et al.
European journal of biochemistry, 241(2), 546-551 (1996-10-15)
The coordination geometry of the metal at the active site in Cd-substituted horse liver alcohol dehydrogenase (LADH) has been investigated for the binary complexes of LADH with imidazole, isobutyramide, decanoic acid and Cl-, and for the ternary complexes of LADH
S P Perrine et al.
Experientia, 49(2), 133-137 (1993-02-15)
The inherited beta-hemoglobinopathies (sickle cell disease and beta thalassemia) are the result of a mutation in the adult (beta) globin gene. The fetal globin chain, encoded by the gamma globin genes, can substitute for the mutated or defective beta globin
S P Perrine et al.
British journal of haematology, 88(3), 555-561 (1994-11-01)
Butyrate and other short-chain fatty acids stimulate fetal globin gene expression and have potential for ameliorating the beta globin disorders. Butyrate, however, is rapidly metabolized in vivo and reaches only micromolar concentrations in plasma. We report here that a branched-chain
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