Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices.

Titanium nanofeaturing for enhanced bioactivity of implanted orthopedic and dental devices.

Nanomedicine (London, England) (2012-12-22)

Terje Sjöström, Alistair S Brydone, R M Dominic Meek, Matthew J Dalby, Bo Su, Laura E McNamara

ABSTRACT

Titanium (Ti) is used as a load-bearing material in the production of orthopedic devices. The clinical efficacy of these implants could be greatly enhanced by the addition of nanofeatures that would improve the bioactivity of the implants, in order to promote in situ osteo-induction and -conduction of the patient's stem and osteoprogenitor cells, and to enhance osseointegration between the implant and the surrounding bone. Nanofeaturing of Ti is also currently being applied as a tool for the biofunctionalization of commercially available dental implants. In this review, we discuss the different nanofabrication strategies that are available to generate nanofeatures in Ti and the cellular response to the resulting nanofeatures. In vitro research, in vivo studies and clinical trials are considered, and we conclude with a perspective about the future potential for use of nanotopographical features in a therapeutic setting.

MATERIALI

N° Catalogo

Marchio

Descrizione del prodotto

348791

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, 99.7% trace metals basis

366994

Sigma-Aldrich

Titanium, powder, <45 μm avg. part. size, 99.98% trace metals basis

267503

Sigma-Aldrich

Titanium, foil, thickness 0.25 mm, 99.7% trace metals basis

268496

Sigma-Aldrich

Titanium, powder, −100 mesh, 99.7% trace metals basis

268526

Sigma-Aldrich

Titanium, sponge, 1-20 mm, 99.5% trace metals basis

460400

Sigma-Aldrich

Titanium, wire, diam. 0.25 mm, 99.7% trace metals basis

GF16031843

Titanium, mesh, 100x100mm, nominal aperture 0.19mm, wire diameter 0.23mm, 60x60 wires/inch, open area 20%, twill weave

369489

Sigma-Aldrich

Titanium, foil, thickness 2.0 mm, 99.7% trace metals basis

348848

Sigma-Aldrich

Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis

348805

Sigma-Aldrich

Titanium, foil, thickness 0.5 mm, 99.99% trace metals basis

767506

Sigma-Aldrich

Titanium, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.995% trace metals basis

GF29374005

Titanium, mesh, 100x100mm, nominal aperture 4.3mm, wire diameter 1.5mm, 4.4x4.4 wires/inch, open area 94%, platinized diamond mesh

460397

Sigma-Aldrich

Titanium, foil, thickness 0.127 mm, ≥99.99% trace metals basis

267481

Sigma-Aldrich

Titanium, foil, thickness 0.25 mm, 99.99% trace metals basis

266035

Sigma-Aldrich

Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis

305812

Sigma-Aldrich

Titanium, 5-10 mm, ≥99.99% trace metals basis (purity exclusive of Na and K content)

348864

Sigma-Aldrich

Titanium, wire, diam. 0.5 mm, 99.99% trace metals basis

GF31127712

Titanium, rod, 10mm, diameter 50mm, 99.99+%

GF14990935

Titanium, tube, 1000mm, outside diameter 10.3mm, inside diameter 8.7mm, wall thickness 0.8mm, annealed, 99.6+%

GF46592949

Titanium, wire, straight, 1000mm, diameter 1.0mm, as drawn, 99.6+%

433667

Sigma-Aldrich

Titanium, evaporation slug, diam. × L 6.3 mm × 6.3 mm, ≥99.99% trace metals basis

267902

Sigma-Aldrich

Titanium, wire, diam. 0.81 mm, 99.7% trace metals basis

GF62977540

Titanium, tube, 200mm, outside diameter 2.03mm, inside diameter 1.63mm, wall thickness 0.2mm, annealed, 99.6+%

GF13900205

Titanium, tube, 100mm, outside diameter 0.51mm, inside diameter 0.35mm, wall thickness 0.08mm, annealed, 99.6+%

GF86399106

Titanium, tube, 500mm, outside diameter 1.6mm, inside diameter 1.2mm, wall thickness 0.2mm, hard, 99.6+%

GF49264713

Titanium, tube, 200mm, outside diameter 1.6mm, inside diameter 1.2mm, wall thickness 0.2mm, hard, 99.6+%

GF43519945

Titanium, wire reel, 2m, diameter 1.0mm, as drawn, 99.99+%

GF95731960

Titanium, tube, 500mm, outside diameter 3.0mm, inside diameter 1.5mm, wall thickness 0.75mm, annealed, 99.6+%

GF52005596

Titanium, tube, 500mm, outside diameter 9.5mm, inside diameter 8.2mm, wall thickness 0.65mm, annealed, 99.6+%

GF04311638

Titanium, rod, 100mm, diameter 6mm, annealed, 99.6+%