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U106

Sigma-Aldrich

(−)-cis-(1S,2R)-U-50488 tartrate

solid

Sinonimo/i:

(−)-(1S,2R)-cis-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide tartrate

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About This Item

Formula empirica (notazione di Hill):
C19H26Cl2N2O · C4H6O6
Numero CAS:
121843-48-9
Peso molecolare:
519.42
Numero MDL:
MFCD00153875
Codice UNSPSC:
12352200
ID PubChem:
24278550

Forma fisica

solid

Colore

white

Solubilità

ethanol: soluble

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(C(O)C(O)=O)C(O)=O.CN([C@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C19H26Cl2N2O.C4H6O6/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;5-1(3(7)8)2(6)4(9)10/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t17-,18+;/m0./s1
DMBKHRMAGYYBJM-CJRXIRLBSA-N

Informazioni sul gene

human ... OPRS1(10280)

Azioni biochim/fisiol

Potent σ receptor ligand.

Nota sulla preparazione

(-)-cis-(1S,2R)-U-50488 tartrate is soluble in ethanol.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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A A Spasov et al.
Eksperimental'naia i klinicheskaia farmakologiia, 74(8), 45-47 (2012-01-12)
A new model is proposed for in vitro testing the efficiency of new chemical substances with kappa-opioid receptor agonist ligand properties.
Amber D Shaffer et al.
Neuroscience letters, 534, 150-154 (2012-12-04)
Previous research has suggested that early-in-life (EIL) exposure to bladder inflammation impairs the function of endogenous opioid inhibitory system(s) and may contribute to the development of chronic bladder pain. This study examined how acute adult and/or prior EIL exposure to
Yu-Wei Chen et al.
Alcohol (Fayetteville, N.Y.), 47(1), 31-38 (2012-12-04)
The opioid system is known to enhance motivated behaviors, including ethanol drinking and food ingestion, by acting in various reward-related brain regions, such as the nucleus accumbens, ventral tegmental area and medial hypothalamus. There is indirect evidence, however, suggesting that
Bassil Hassan et al.
Regional anesthesia and pain medicine, 38(1), 21-27 (2012-12-12)
κ-Opioid receptor (κ-OR) activation is known to play a role in analgesia and central sedation. The purpose of the present study was to examine the effect of the κ-OR agonist, U-50488 (an arylacetamide), on Ca channel currents and the signaling
Thiago M Cunha et al.
Molecular pain, 8, 10-10 (2012-02-10)
In addition to their central effects, opioids cause peripheral analgesia. There is evidence showing that peripheral activation of kappa opioid receptors (KORs) inhibits inflammatory pain. Moreover, peripheral μ-opioid receptor (MOR) activation are able to direct block PGE(2)-induced ongoing hyperalgesia However
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