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Key Documents

SRP6319

Sigma-Aldrich

Kininogen,LMW from human plasma

≥95% (SDS-PAGE)

Sinonimo/i:

Alpha-2-thiol proteinase inhibitor, BDK, Fitzgerald factor, High molecular weight Kininogen, KNG, Kininogen-1 heavy chain, Low molecular weight growth-promoting, Williams-Fitzgerald-Flaujeac factor

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About This Item

Codice UNSPSC:
12352200

Origine biologica

human plasma

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized

PM

65 kDa

Confezionamento

pkg of 100 μg

N° accesso UniProt

P01042

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... KNG1(3827)

Descrizione generale

KNG1 (kininogen 1) gene is localized to human chromosome 3, and codes for both high and low molecular weight kininogen. The high molecular weight kininogen (HK) is a 120kDa single chain glycoprotein.
LMW Kininogen is involved in blood pressure regulation since it is an endogenous protein substrate for tissue kallikrein. Proteolytic cleavage by kallikrein releases vasoactive bradykinin from LMW kininogen. In addition, LMW kininogen, like HMW kininogen, is a major extracellular cysteine protease inhibitor.

Azioni biochim/fisiol

KNG1 (kininogen 1) exists in low and high molecular weight forms which are precursors for bradykinin and kallidin (Lys-Bradykinin), respectively. The high molecular weight kininogen (HK) functions as a cofactor for the stimulation of surface-bound Hageman factor (Factor XII) by kallikrein. HK is subsequently required for the activation of prekallikrein and Factor XI by the activated Hageman factor. These steps are essential for the initiation of coagulation, fibrinolysis, and the production of vasoactive peptides. Ile581Thr polymorphism in KNG1 gene is linked with increased susceptibility to venous thrombosis.

Stato fisico

Lyophilized from 10 mM Na acetate, pH 5.5 with 200 mM NaCI .

Ricostituzione

In water or aqueous buffer

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H315,H319,H334,H335

Classi di pericolo

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes.
Lieb W, et al.
Circulation. Cardiovascular Genetics, 8(1), 131-140 (2015)
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.
Houlihan LM, et al.
American Journal of Human Genetics, 86(4), 626-631 (2010)
The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as determined by electron microscopy.
Weisel JW, et al.
The Journal of Biological Chemistry, 269(13), 10100-10106 (1994)
KNG1 Ile581Thr and susceptibility to venous thrombosis.
Morange PE, et al.
Blood, 117(13), 3692-3694 (2011)

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