SRP4928
Lipocalin-2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinonimo/i:
25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥95% (HPLC)
≥95% (SDS-PAGE)
Forma fisica
lyophilized
PM
~20 kDa
Confezionamento
pkg of 50 μg
tecniche
activity assay: suitable
Impurezze
endotoxin, tested
N° accesso NCBI
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... LCN2(3934)
Descrizione generale
Research area: Cell signaling. The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34. LCN2, a secreted glycoprotein, is an adipokine. It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells, and cardiomyocytes. LCN2 belongs to the lipocalin family. LCN2 consists of the lipid binding domain that binds to small hydrophobic molecules and the ligand binding cavity that binds to bacterial and mammalian proteins called siderophores.
Applicazioni
LCN2 (lipocalin 2)-human has been used in the cell proliferation assay.It has also been used in conductometric immunoassay in renal carcinoma cells.
Azioni biochim/fisiol
LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation. LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis. It is an early marker of acute kidney injury, cardiovascular diseases, lupus nephritis, and intestinal inflammation. LCN2 is upregulated in humans with heart failure. It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability. Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder, and kidney cancers.LCN2 acts as a pleiotropicmolecule and plays a role in several pathophysiological and physiologicalactivities including immune response, inflammation, metabolic homeostasis, andinfection.
Stato fisico
Lyophilized with no additives.
Ricostituzione
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Vanessa Abella et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 20(8), 565-571 (2015-12-17)
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to
Network based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma.
Wu B
Scientific Reports, 4, doi: 10-doi: 10 (2014)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans.
Catalan V
Journal of Molecular Medicine, 87, 803-813 (2009)
Plasma levels of neutrophil gelatinase-associated lipocalin in children with heart failure.
Tawfeek MS
Therapeutic Advances in Cardiovascular Disease, 10, 30-36 (2016)
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