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Merck
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Documenti fondamentali

SRP2080

Sigma-Aldrich

BRCA1 human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Sinonimo/i:

BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PSCP, RNF53

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.26

Origine biologica

human

Ricombinante

expressed in insect cells

Saggio

≥70% (SDS-PAGE)

Stato

frozen liquid

PM

~209 kDa

Confezionamento

pkg of 20 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Concentrazione

350 μg/mL

Colore

clear
 colorless

N° accesso NCBI

NM_007296

N° accesso UniProt

P38398

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... BRCA1(672)

Azioni biochim/fisiol

The human BRCA1, the product of breast and ovarian cancer gene 1, is a hyperphosphorylated protein functioning as a tumor suppressor involved in both transcription regulation and DNA repair. BRCA1 associates with RAD51 and has shown to be required for transcription-coupled repair of DNA damage as well as for the repair of chromosomal double-strand breaks. Association with a human SWI/SNF-related complex has recently suggested a potential role of BRCA1 in linking chromatin remodeling to breast cancer.

Stato fisico

Clear and colorless frozen liquid solution

Nota sulla preparazione

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
63028149
093014043

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Corinne Chabalier-Taste et al.
Oncotarget, 7(3), 2269-2283 (2016-01-09)
Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles
S K Sharan et al.
Nature, 386(6627), 804-810 (1997-04-24)
Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now defined and an interaction identified of the Brca2 protein with the DNA-repair
E Maldonado et al.
Nature, 381(6577), 86-89 (1996-05-02)
We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators
R Scully et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(11), 5605-5610 (1997-05-27)
The familial breast-ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme over multiple chromatographic steps. Other tested transcription activators that

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