SML3880

CST626

≥98% (HPLC)

• Sinonimo/i: (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)-propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide, IAP-VHL hetero-PROTAC 9
• Formula empirica (notazione di Hill): C₆₁H₈₂N₈O₉S
• Peso molecolare: 1103.42
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: -10 to -25°C

Descrizione

Azioni biochim/fisiol

BIR domain-targeting degrader of inhibitor of apoptosis proteins (IAPs) cIAP1/2 and XIAP.



CST626 is a degrader of cellular inhibitor of apoptosis (IAP) proteins (cIAP1/cIAP2/XIAP DC50 post 16h = 2.4/6.2/0.7 nM with >99% degradation observed post 3h treatment at 100 nM; MM1S cells) that effectively reduces the viability of hematological cancer cultures, including MM (IC50 post 96h = 8.5 nM/NCI-H929, 1.14µM/JJN3, 2.54 µM/RPMI-8826), AML (IC50 post 96h = 2.1 nM/MOLM13, 420 nM/K562, 1.17 µM/HEL) and DLBCL (IC50 post 96h = 1.6 nM/SUDHL6, 460 nM/DB, 1.69 µM/SUDHL4). CST626 is composed of a von Hippel-Lindau (VHL) ligand VH032 derivative linked to a monovalent Smac (DIABLO) AVPI motif-based IAP BIR domain-targeting ligand.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable