SML3693
RA839
≥98% (HPLC)
Sinonimo/i:
(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid, RA 839
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About This Item
Formula empirica (notazione di Hill):
C25H28N2O4S
Numero CAS:
Peso molecolare:
452.57
Numero MDL:
Codice UNSPSC:
12352200
NACRES:
NA.21
Livello qualitativo
Saggio
≥98% (HPLC)
Forma fisica
powder
Colore
, White to light brown
Solubilità
DMSO: 2 mg/mL, clear
Temperatura di conservazione
-10 to -25°C
Azioni biochim/fisiol
RA839 is an active in vivo, highly selective and potent activator of Nrf2 (transcription factor NF-E2-related factor 2) signaling. RA839 binds noncovalently to the Nrf2-interacting kelch domain of Keap1 thereby inhibiting the interaction between Keap1 and Nrf2. RA839 inhibits the induction of both inducible nitric oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA-839 is a potent antagonist of Rotavirus propagation in vitro that inhibits viral RNA and protein expression.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Upayan Patra et al.
Antiviral research, 161, 53-62 (2018-11-23)
Acute watery diarrhea due to Rotavirus (RV) infection is associated with high infantile morbidity and mortality in countries with compromised socio-economic backgrounds. Although showing promising trends in developed countries, the efficacy of currently licensed RV vaccines is sub-optimal in socio-economically
Kim T Tran et al.
Journal of medicinal chemistry, 62(17), 8028-8052 (2019-08-15)
Inhibiting the protein-protein interaction (PPI) between the transcription factor Nrf2 and its repressor protein Keap1 has emerged as a promising strategy to target oxidative stress in diseases, including central nervous system (CNS) disorders. Numerous non-covalent small-molecule Keap1-Nrf2 PPI inhibitors have
Angelika F Winkel et al.
The Journal of biological chemistry, 290(47), 28446-28455 (2015-10-16)
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors, the activity of Nrf2 is inhibited by its interaction with the Keap1 (kelch-like
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