SML3207

MB05032

≥98% (HPLC)

• Sinonimo/i: 2-Amino-5-isobutyl-4-[5-phosphono-2-furanyl]thiazole, 5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid, CS-917 active drug, MB 05032, MB-05032, MB-06322 active drug, MB06322 active drug, [5-[2-Amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
• Formula empirica (notazione di Hill): C₁₁H₁₅N₂O₄PS
• Numero CAS: 261365-11-1
• Peso molecolare: 302.29
• Numero MDL: MFCD14584901
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear (warmed)
• Temperatura di conservazione: −20°C
• InChI: 1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16); XJMYIJPPDSZOPN-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

MB05032 is an AMP site-targeting, potent and selective fructose-1,6-bisphosphatase (FBPase) inhibitor (rec hum liver FBPase IC50 = 16 nM, purified hum muscle/rat liver FBPase IC50 = 29/61 nM) with no potency toward glycogen phosphorylase or AMP-activated protein kinase. MB05032 inhibits cellular (rat/human hepotocytes IC50/glucose gluconeogenesis (GNG) substrate = 7.8 ?M/lactate & pyruvate/rat hepotocytes, 47.5 μM/lactate/human hepotocytes).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable